We’re in the business of helping people restore their hair and appearance, so we couldn’t help but notice published research findings that demonstrated significant hair regrowth in alopecia patients. Individuals diagnosed with alopecia, an autoimmune disease in which the immune system attacks healthy hair follicles, can cause the loss of body hair. Columbia University researchers not only implicated a specific immune cell, namely CD8+NKG2D+ T cells, as a primary cause of alopecia, they successfully implemented a molecular treatment protocol to restore hair growth in both mice and humans. 

Alopecia Areata

Columbia University researchers, Raphael Clynes and Angela Christiano, repurposed a bone marrow disorder drug licensed in the United Kingdom to help restore the hair growth of three alopecia areata sufferers. It is reported that four to five million men and women have been diagnosed with alopecia in the United States alone. The researchers concluded that JAK 1/2 protein inhibitors, including ruxolitinib, tofacitinib and similar compounds currently in development, offer hope for those suffering from alopecia. Development of a safe and effective drug for the routine treatment of alopecia will require additional human studies.

The promising laboratory research also identified a number of signaling molecules that appear to be responsible for driving the T cell activity that produces the alopecia disease. In the study, three human participants diagnosed with moderate to severe alopecia areata experienced nearly normal hair growth after receiving ruxolitinib treatments for three to five months. The research findings are especially promising because there is presently no proven drug treatment for alopecia sufferers. It should also be mentioned that ruxolitinib has not been licensed for treating alopecia. This will require extensive clinical trials.

JAK Protein Inhibitors

The Columbia research findings, published in the online science journal, Nature Medicine, indicated that the hair follicles of alopecia sufferers send out erroneous signals to the immune system. The immune system then attacks the otherwise healthy follicles, resulting in loss of hair. JAK protein inhibitors, a relatively new class of drugs intended to treat diseases such as bone marrow cancer and Rheumatoid arthritis, seem to be effective at blocking the signaling process.

A total of 12 humans have received ruxolitinib treatments to date. Only the first three participants were included in the recently released study. Hair replacement treatment with ruxolitinib is still experimental, but Apollo Hair Restoration can provide effective surgical and non-surgical hair restoration services right now. Call 1-800-339-4247 to schedule a free hair restoration evaluation. Your appearance really does matter.

The market is awash in a wide array of different types of products that are said to be beneficial in preventing hair loss and in promoting health hair growth. Although many consumers maintain that they have benefited from these various products, a reality is that a health diet that focuses on certain types of essential nutrients is demonstrated to be beneficial in assisting in healthier hair for men and women alike.

The Importance of Protein

Hair consists almost entirely of protein. For this reason, an appropriate amount of protein is necessary in a diet if a person desires to attempt to control hair loss and to promote a healthier head of hair overall.

With a healthy head of hair, about 90 percent is in the growing phase -- provided a person ingests a proper amount of protein. If a person does not consume an appropriate level of protein on a regular basis, a smaller portion of hair will be in the growing phase. The larger the percentage of hair that enters into a resting phase, the more hair a person loses. 

As a general rule, an adult woman should consume a bit over 40 grams of protein daily while an adult should consume a bit over 50 grams of protein each day. An individual does not need to pack on the protein to enhance overall hair health. Rather, a person need only make sure that he or she consumes an appropriate amount on a consistent basis.

Iron Deficiency

Although more common among women, iron deficiency contributes to hair loss. Women must be particularly conscious that they maintain enough iron in their diets on a consistent basis to ward off unwanted hair loss and maintain overall good health.

Vitamins and Hair Health

In order to foster healthy hair, a person must consumer the recommended daily allowance of vitamins identified as necessary for overall health. Researchers generally have concluded that a deficiency in any one of the vitamins that are recommended as part of a health diet ultimately can result in less healthy hair and an increase in hair loss. This holds true for both men and women alike.

Foods that Contribute to Hair Loss

Some research suggests that food items that score high on the glycemic index may contribute to hair loss. These types of food items include bottled or canned fruit juices, margarine, white bread and while rice.

Alopecia is the general medical term for hair loss.

Types of hair loss

There are many types of hair loss with different symptoms and causes. Some of the more common types of hair loss are described below.

Male- and female-pattern baldness

Male-pattern baldness is the most common type of hair loss. As well as affecting men, it can sometimes affect women (female-pattern baldness). It can be particularly difficult for both men and women to cope with.

Male-pattern baldness follows a pattern of a receding hairline, followed by thinning of the hair on the crown and temples. During female-pattern baldness, hair usually only thins on top of the head.

Male- and female-pattern baldness is also called androgenic or androgenetic alopecia. Male-pattern baldness is a condition that runs in families, but it is not clear if this is the case with female-pattern baldness.

Alopecia areata

Alopecia areata is patches of baldness that may come and go. It can occur at any age, but mostly affects teenagers and young adults. Six out of 10 people affected develop their first bald patch before they are 20 years old.

Alopecia areata is thought to be caused by a problem with the immune system (the body's natural defence against infection and illness). It is also believed that some people's genes make them more susceptible to alopecia areata, as one in five people with the condition have a family history of the condition. In many cases the hair grows back after about a year.

Scarring alopecia

Scarring alopecia, also known as cicatricial alopecia, is hair loss that can occur as a result of complications from another condition. In this type of alopecia, the hair follicle (the small hole in your skin that an individual hair grows out of) is completely destroyed. This means your hair will not grow back.

Conditions that can cause scarring alopecia include lichen planus (an itchy rash affecting many areas of the body) and discoid lupus (a mild form of lupus affecting the skin, causing scaly marks and hair loss).

Anagen effluvium

Anagen effluvium is widespread hair loss that can affect your scalp, face and body. One of the most common causes of this type of hair loss is the cancer treatment chemotherapy.

It may be possible to reduce hair loss from chemotherapy by wearing a special cap that keeps the scalp cool. However, scalp cooling is not always effective and not widely available.

In most cases, hair loss in anagen effluvium is temporary. Your hair should start to grow back a few months after chemotherapy has stopped.

Telogen effluvium

Telogen effluvium is a common type of alopecia where there is widespread thinning of the hair, rather than specific bald patches. Hair is shed from the scalp, usually as a reaction to stress or medication. This type of hair loss tends to improve without treatment after a few months.

Read more about the symptoms of hair loss and the causes of hair loss.

How is hair loss treated?

More common types of hair loss, such as male-pattern baldness, do not need treatment because they are a natural part of ageing and do not pose a risk to your health.

However, any type of hair loss can be distressing, so you should see your GP if you are worried about it.

Your GP should be able to diagnose your type of hair loss by examining your hair, and they can also discuss possible treatments with you. It is advisable to visit your GP before you try a private consultant dermatologist (skin care specialist).

If you wish to seek treatment for male-pattern baldness for cosmetic reasons, two medications called finasteride and minoxidil can be used. Minoxidil can also be used to treat female-pattern baldness.

However, these treatments are not effective for everyone and only work for as long as they are continued. These treatments are also not available on the NHS and can be expensive.

Alopecia areata is usually treated with steroid injections, although it is sometimes possible to use a steroid cream, gel or ointment. A treatment called immunotherapy may also be used. This involves stimulating hair growth by causing an intentional allergic reaction in the affected areas of skin.

If you have significant hair loss of any type, you may decide to wear a wig. Wigs are available on the NHS, but you may have to pay for one unless you qualify for help with charges.

There are also some surgical options for hair loss, including a hair transplant and artificial hair implants.

Read more about diagnosing hair loss and treating hair loss.

Emotional issues

Hair loss can be difficult to come to terms with. The hair on your head can be a defining part of your identity. It reflects the image you have of yourself and how you want others to see you.

If you start to lose your hair, it can feel as if you are losing part of your identity. This can affect your self-confidence and sometimes lead to depression.

Speak to your GP if you are finding it difficult to deal with your hair loss. They may suggest counselling, which is a type of talking therapy where you can discuss your issues with a trained therapist.

You may benefit from joining a support group or speaking to other people in the same situation – for example, through online forums.

A number of charities, such as Alopecia UK, have support groups and online forums where you can talk to others who are experiencing hair loss. 

Source: NHS